. POLYOX resins are nonionic polyethylene oxide solubility polymers. Regulatory Information q9;v80 Avicel Microcrystalline Cellulose Physical Properties. FMC, JRS and Mingtai were estimated to hold for . It is also used in plaque assays for counting. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication ( EMCOCEL 90 M. 130. Alginates also function as actives in some anti-reflux products. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. SCMm_>x^O9l (n. The aqueous solution to barrier membrane coating. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. . Fiber supplements can lessen the absorption of some . Are you sure you want to delete your template? The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. : 9004-34-6 Date Approved: 01/31/2008 . Hi, let us know if you have any questions as you visit our website. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Combines good flow and high compactibility. CAS #: 9004-34-6 Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. [FMC Study Number I92-1464]. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. <<
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Truly distinctive drug delivery solutions. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. No. It is, however, a good source of fibre. HMo@9, U Q!R/1*;` Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Packaging: 34 x 50 kgs fiber drums. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Looking for FMC'searnings news? >>
. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. CAS 9004-34-6. "R}~Q:~pgg'"l/O:OV~
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Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. 0.25 - 0.37. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Aqueous suspensions of microcrystalline cellulose have . The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. <>
Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Home. . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. PDF (2.77 mb) 2021 FMC Sustainability Report. Instead, they obtained a stable colloidal suspension. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. endobj
The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. EMCOCEL XLM 90. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C
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g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Gloves, eye protection and a dust mask should be used. B;vLZpHU%ChUyD+[ To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Microcrystalline Cellulose. PDF (28.38 mb) 2022 Corporate Fact Sheet. Product Name: Microcrystalline Cellulose 1.2. It is hygroscopic and insoluble in water. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. <>
They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. G2W4de=u183KGH{ vQ#4:1\wc However, consumption of large quantities of the material may have a laxative effect. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). pfTr^i5wOg)y .6
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{vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. MATERIAL SAFETY DATA SHEET. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Battista, O. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . %PDF-1.4
Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . : 5. Microcrystalline Cellulose NF. <<
The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. 1.3. A family of polysaccharide products that allow distinctive drug delivery solutions. Microcrystalline Cellulose / Avicel PH-102. ( Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Delivering efficient and robust formulations. %
Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Microcrystalline Cellulose (MCC) MSDS 1. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Watch Now. endobj
High performance lubricant that brings more to the tablet. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. The table below shows the most common physicochemical parameters of this raw material. : 51395-75-6 Date Approved: 01/31/2008 Revision No. No. Remove Biologicals by FMC. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. There have always been two different points of view for the liquidity of MCC. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Avicel PH-200 microcrystalline cellulose NF, Ph. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. This Microcrystalline Cellulose . II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. stream
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Browse Avicel PH-101 and related products at MilliporeSigma. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>>
Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Micro Crystalline Cellulose. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR
e,cqO! These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. If you are already a ChemPoint customer then sign up for access to our online ordering website. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Safety Data Sheet for Cellulose microcrystalline 102331. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. 3 0 obj
Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Learn about FMC's differentiated biologically-based crop solutions. Product Name: Microcrystalline Cellulose E460 1.2. stream
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